Istituto di Scienza e Tecnologie dell'Informazione     
Palleschi V., Pagani L., Pagnotta S., Amato G., Tofanelli S. Application of graph theory to the elaboration of personal genomic data for genealogical research. In: PeerJ Computer Science, PeerJ Computer Science, [Online First 14 October 2015]
In this communication a representation of the links between DNA-relatives based on Graph Theory is applied to the analysis of personal genomic data to obtain genealogical information. The method is tested on both simulated and real data and its applicability to the field of genealogical research is discussed. We envisage the proposed approach as a valid tool for a streamlined application to the publicly available data generated by many online personal genomic companies. In this way, anonymized matrices of pairwise genome sharing counts can help to improve the retrieval of genetic relationships between customers who provide explicit consent to the treatment of their data.
URL: http://https://peerj.com/articles/cs-27/
DOI: 10.7717/peerj-cs.27
Subject DNA analysis
Personal genomics
Ancestry reconstruction
Statistical methods
Graph Theory
Genetic genealogy
G.2.2 Graph Theory
G.3 PROBABILITY AND STATISTICS. Statistical computing

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