Istituto di Scienza e Tecnologie dell'Informazione     
D'Acunto M., Chiono V., Sartori S., Rechichi A., Tonda-Turo C., Vozzi G., Vozzi F., Salvadori C., Dini F., Barsotti G., Carlucci F., Burchielli S., Nicolino S., Audisio C., Perroteau I., Giusti P., Ciardelli G. Poly(ester urethane) guides for peripheral nerve regeneration. In: Macromolecular Bioscience, vol. 11 (2) pp. 245 - 256. Wiley, 2011.
A biocompatible and elastomeric PU was synthesized from low-molecular-weight PCL as macrodiol, CMD as chain extender and HDI as chain linker for applications in the field of peripheral nerve repair. PU cast films supported in vitro attachment and proliferation of NOBEC. The in vitro adhesion and proliferation of S5Y5 neuroblastoma cells on the inner surface of uncoated, gelatin- and PL-coated PU guides were compared. Due to their superior in vitro performance, PL-coated PU guides were tested in vivo for the repair of 1.8 cm-long defects in rat sciatic nerves. The progressive regeneration was confirmed by EMG and histological analysis showing the presence of regenerating fibers in the distal stumps.
In questo lavoro e' stato sviluppato uno scaffold basato su Poliuretano per la rigenerazione di cellule di neuroblastoma S5Y5. La progressiva rigenerazione e' stata confermata da studi istologici e dall'analis elettromiografica.
URL: http://onlinelibrary.wiley.com/doi/10.1002/mabi.201000354/abstract;jsessionid=6D44EBCEABC61E0DEE0F03A9888347F8.d02t02
DOI: 10.1002/mabi.201000354
Subject Nerve Rigeneration
C.3 Special-Purpose and Application-Based Systems

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