PUMA
Istituto di Scienza e Tecnologie dell'Informazione     
D'Acunto M. Nanovectors for drug delivery: long-lived pore dynamics for swelling liposomes. In: Mechanics Research Communications, vol. 38 (1) pp. 34 - 37. Elsevier, 2011.
 
 
Abstract
(English)
A liposome is a spherical, bilayer vesicle separating the interior volume containing an aqueous solution, from an exterior suspension. A fundamental practical application provides the liposome used as vehicles for drug delivery. In this case, liposomes are designed to contain a specific drug or a gene needed to fight the disease. If a vesicle containing high internal solute concentration is placed inside a dilute solution, the osmotic flux of solvent into the interior can lead to its rupture or a formation of pores. Such pores can be long-lived pores or short-lived pores suddenly closing after their formations. Long-lived pores lead to a well controlled drug delivery. In this paper, we show that the existence of long-lived pores is completely conditioned only by the pore dynamics, and that the long-lived pore dynamics is highly stable because sustained by a limit cycle. Moreover, we calculate analytically the frequency of a long-lived pore making use of the He's variational method.
Abstract
(Italiano)
I liposomi possono essere considerati un ottimo nanovettore capace di portare un farmaco su un bersaglio definito, come, ad esempio, una cellula tumorale. Questa caratteristica e', in particolare, amplificata se il liposoma presenta dei pori di lunga durata sulla propria superficie. In questo lavoro si dimostra che sotto alcune condizioni i pori di lunga durata sono possibili in quanto sostenuti da una dinamica auto-eccitata che colloca la dinamica del poro su un ciclo limite. Sotto queste condizioni, il rilascio del farmaco avviene in condizioni controllate.
URL: http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235752%232011%23999619998%232899758%23FLA%23&_cdi=5752&_pubType=J&view=c&_auth=y&_acct=C000061181&_version=1&_urlVersion=0&_userid=3967543&md5=5f4660f8b7ed7392a0fcfebcac7e7c21
DOI: 10.1016/j.mechrescom.2010.11.002
Subject liposomi
nanovettori
C.3 Special-Purpose and Application-Based Systems
68N30


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