Istituto di Scienze Marine     
Chelossi E., Pantile R., Pronzato R., Milanese M., Hentschel U. Bacteria with antimicrobial properties isolated from the Mediterranean sponges Chondrilla nucula and Petrosia ficiformis. In: Aquatic Microbial Ecology, vol. 49 (2) pp. 157 - 163. Inter-Research, 2007.
Bacteria were isolated seasonally from the Mediterranean sponges Chondrilla nucula and Petrosia ficiformis and screened for antibacterial activities. Selected isolates were taxonomically identified by 16S rRNA gene sequencing. A total of 416 different bacterial strains were isolated, 60 (14.4 %) of which displayed variable degrees of antimicrobial activity. Of the bioactive strains, 58.3 % were able to inhibit Staphylococcus aureus, 6.7 % were active against Bacillus subtilis, 11.7 % against both Enterococcus faecalis and Escherichia coli, 38.3 % against Pseudoalteromonas atlantica and 33.3 % against Pseudomonas elongata. 16S rRNA gene sequence analysis showed that 2 isolates, 1 from seawater samples and 1 from P. ficiformis, were most closely related to Bacillus subtilis (99 % similarity) and that another isolate from P, ficiformis was most closely related to a previously described sponge-associated Alphaproteobacterium NW001 (98% similarity). Two isolates from C. nucula were most closely related to Brachybacterium paraconglomeratum (99 % similarity) and Shewanella algae (89 % similarity). The high percentage of bioactive isolates derived from the 2 sponges suggests that marine microorganisms, whether animal-associated or planktonic, are promising sources for drug discovery.
DOI: 10.3354/ame01134
Subject antimicrobial activity
associated bacteria
Chondrilla nucula
Petrosia ficiformis

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