PUMA
Istituto di Ingegneria Biomedica     
Schaller G., Kretschmer S., Gouya G., Haider D. G., Mittermayer F., Riedl M., Wagner O., Pacini G., Wolzt M., Ludvik B. Alcohol acutely increases vascular reactivity together with insulin sensitivity in type 2 diabetic men. In: Experimental and Clinical Endocrinology & Diabetes, vol. 118 (1) pp. 57 - 60. Thieme Journals, 2010.
 
 
Abstract
(English)
Moderate alcohol consumption is associated with increased insulin sensitivity and reduced cardiovascular risk. We hypothesized that this relates to a direct effect of alcohol and therefore investigated whether acute alcohol intake altered insulin sensitivity or endothelial function in patients with type 2 diabetes. In an open-label two period design, the effect of a single oral dose of 40 g of alcohol (168 ml 40% vodka) on an insulin-modified frequently sampled intravenous glucose tolerance test (FSIGT) and on endothelium-dependent (flow mediated, FMD) or endothelium-independent (glyceroltrinitrate (GTN)-induced) vasodilation of the brachial artery measured by ultrasound was studied. Experiments were carried out in twelve male patients with type 2 diabetes mellitus (64+/-6 years, body mass index 28.4+/-5.7 kg/m (2)). Baseline insulin sensitivity index (S (I)) was 1.10+/-0.34 min (-1).microU (-1).ml, baseline FMD was +4.1+/-3.0%, and GTN-induced vasodilation +7.4+/-2.3% from resting brachial artery diameter. Acute alcohol intake increased alcohol plasma levels to 0.33+/-0.04 per thousand, S (I) to 1.86+/-0.45 min (-1).microU (-1).ml (p<0.05), and FMD to +8.2+/-2.8% (p<0.05), while GTN-induced dilation remained unchanged. No relationship was detectable between the observed changes. We conclude that alcohol intake acutely increases endothelium-dependent brachial artery vasodilation in patients with type 2 diabetes together with insulin sensitivity. This acute effect might explain some beneficial effects of low alcohol consumption in epidemiological observations.
URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19834876
Subject Alcohol Drinking
Brachial Artery/drug effects/physiopathology/ultrasonography
Diabetes Mellitus, Type 2/physiopathology
Endothelium, Vascular/drug effects/physiopathology
Ethanol/administration & dosage/blood/pharmacology
Glucose Tolerance Test/methods
insulin resistance
Nitroglycerin/pharmacology
Vasodilation/drug effects


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