Istituto di Ingegneria Biomedica     
Rijkelijkhuizen J. M., Girman C. J., Mari A., Alssema M., Rhodes T., Nijpels G., Kostense P. T., Stein P., Eekhoff E. M., Heine R., Dekker J. M. Classical and model-based estimates of beta-cell function during a mixed meal vs. an OGTT in a population-based cohort. In: Diabetes Research and Clinical Practice, vol. 83 (2) pp. 280 - 8. Elsevier, 2009.
This study compared classical and model-based beta-cell responses during an oral glucose tolerance test (OGTT) and a meal tolerance test (MTT) in a population-based cohort. Individuals with normal glucose metabolism (NGM, n=161), impaired glucose metabolism (IGM, n=19) and type 2 diabetes mellitus (DM, n=20) underwent a 75 g-OGTT and an MTT (75 g carbohydrates, 50 g fat, 24 g proteins). Classical estimates of beta-cell function (insulinogenic index and the ratio of areas under insulin and glucose curves) were calculated. Mathematical modelling was used to determine beta-cell glucose sensitivity, rate sensitivity and potentiation. Insulin sensitivity was characterized by three surrogate estimates. Both classical and model-based estimates of beta-cell function were higher during MTT than during OGTT (P<0.05). Regarding the model-based parameters, especially beta-cell sensitivity was increased following MTT as compared with OGTT (P<0.05). Both during OGTT and MTT, across most parameters describing beta-cell function, the largest reduction in beta-cell response occurred between IGM and DM, while the largest reduction in insulin sensitivity occurred between NGM and IGM. We conclude that beta-cell response is stronger after a mixed meal than after an OGTT with equal carbohydrate quantity, both for classical and model-based parameters. The higher response was mostly explained by higher beta-cell sensitivity during the meal
URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19097663
DOI: 10.1016/j.diabres.2008.11.017
Subject Insulin secretion
Insulin sensitivity
Beta-cell glucose sensitivity
Mixed meal
General population

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