PUMA
Istituto di Ingegneria Biomedica     
Scopinaro F., Tofani A., Di Santo G., Di Pietro B., Lombardi A., Lo Russo M., Soluri A., Massari R., Trotta C., Amanti C. High resolution, hand held camera for sentinel node detection. In: Cancer Biotherapy and Radiopharmaceuticals, vol. 23 pp. 43 - 52. Mary Ann Liebert Inc. Publisher, 2008.
 
 
Abstract
(English)
Background: The imaging probe (IP) is a high-resolution (HR), 1-in2 field-of-view hand-held gamma camera. We used it to detect breast cancer sentinel node (SN). Patients and Methods: We divided 120 T1 breast cancer patients, who underwent Anger camera lymphoscintigraphy (ACL), in two subgroups of 60 patients who were age, body mass index, and cancer size matched: subgroup A (SA) and B (SB). SN was detected with a common gamma probe (GP) in SA, with IP plus GP in SB. Results: Surgeons removed radioactive nodes without exceeding four nodes. Eighty-two (82) SNs were taken off in SA and 105 in SB (p < 0.01). Of SA, 22 of 60 patients and 36 of 60 patients of SB showed more than 1 node, and 3 of them showed 3 nodes and 1 showed 4 nodes. Thirteen (13) patients resulted N+ (21.6%) in SA. Ten (10) patients of SA showed an invasion on the hottest nodes and 3 on the second nodes. In the SB, 18 patients (25%) showed invasion. Sixteen (16) invasions were on hot, 4 on second, and 1 on the third node. Withdrawal time of SN was 11.25 4.7 minutes for SA and 7.4 2.8 minutes for SB (p < 0.025). Conclusions: SN biopsy with IP is fast and discovers more SNs and more invasions than ACL.
URL: http://www.liebertonline.com/doi/abs/10.1089/cbr.2007.364
Subject breast cancer
sentinel-node biopsy
imaging probe
radioguided surgery
micrometasteses


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