PUMA
Istituto di Ingegneria Biomedica     
Farhan S., Winzer C., Tura A., Quehenberger P., Bieglmayer C., Wagner O., Huber K., Waldhäusl W., Pacini G., Kautzky-Willer A. Fibrinolytic dysfunction in insulin-resistant women with previous gestational diabetes. In: European Journal of Clinical Investigation, vol. 36 pp. 345 - 52. Wiley, 2006.
 
 
Abstract
(English)
BACKGROUND: Women with a history of gestational diabetes (p-GDM) are at increased risk of developing type 2 diabetes mellitus (DM2) later in life, and therefore at increased risk for future cardiovascular disease. MATERIALS AND METHODS: Three months after delivery we investigated the plasma levels of plasminogen activator inhibitor type 1 (PAI-1), tissue plasminogen activator (t-PA), fibrinogen and von Willebrand factor (vWF) in 74 women with p-GDM and 20 healthy females with normal glucose tolerance during and after pregnancy, as well as the relation of fibrinolytic parameters to insulin resistance and glycaemic control. All women underwent an oral (OGTT) as well as an intravenous glucose tolerance test (FSIGT). Mathematical model analysis disclosed that 50% (n=37 each) of the p-GDM subjects had normal (NIS) or impaired (IIS) insulin sensitivity. Parameters of interest were determined using commercially available test systems. RESULTS: Women with p-GDM and IIS had significantly increased body fat mass (BFM) (P
URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16634839&dopt=Citation
DOI: 10.1111/j.1365-2362.2006.01630.x
Subject Gestational diabetes
fibrinolytic function
insulin sensitivity
obesity
PAI-1
proinsulin


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