PUMA
Istituto di Ingegneria Biomedica     
Basili S., Pacini G., Guagnano M., Manigrasso M., Santilli F., Pettinella C., Ciabattoni G., Patrono C., Davý G. Insulin resistance as a determinant of platelet activation in obese women. In: Journal of the American College of Cardiology, vol. 48 (12) pp. 2531 - 8. Elsevier, 2006.
 
 
Abstract
(English)
Insulin resistance, per se, might contribute to increased platelet activation observed in obesity, independently of underlying inflammation. Forty obese women had significantly higher 11-dehydro-thromboxane B2 (11-dehydro-TXB2) excretion, an index of platelet activation, C-reactive protein, and CD40 ligand levels and lower SI, an index of insulin sensitivity and adiponectin, than healthy controls. Waist-to-hip ratio and SI predicted 11-dehydro-TXB2, independently of adiponectin, inflammatory, and lipid patterns. Improved insulin sensitivity achieved with either successful weight loss or pioglitazone treatment significantly decreased thromboxane biosynthesis in obese women. Thus, insulin resistance is a major determinant of platelet activation in female obesity.
URL: http://www.ncbi.nlm.nih.gov/pubmed/17174194
DOI: 10.1016/j.jacc.2006.08.040
Subject insulin resistance
female obesity


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