Istituto di Ingegneria Biomedica     
Ferranini E., Gastaldelli A., Miyazaki Y., Masafumi M., Mari A., Defronzo R. A. Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. In: Journal of Clinical Endocrinology & Metabolism, vol. 90 (1) pp. 493 - 550. The Endocrine Society, 2005.
The nature of the progressive beta-cell failure occurring as normal glucose tolerant (NGT) individuals progress to type 2 diabetes (T2DM) is incompletely understood. We measured insulin sensitivity (by a euglycemic insulin clamp) and insulin secretion rate (by deconvolution of plasma C-peptide levels during an oral glucose tolerance test) in 188 subjects [19 lean NGT (body mass index [BMI]
URL: http://jcem.endojournals.org/cgi/content/abstract/90/1/493
Subject Glucose Tolerance Test
Insulin Resistance
Glucose Tolerance Test
Blood Glucose/analysis

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