Istituto di Informatica e Telematica     
El Baroudi M., La Sala D., Cinti C., Capobiano E. DAC-driven Integrative Network Regulation and Pathway Coordination in Breast Cancer. In: International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2013, vol. 1 pp. 413 - 425. Ignacio Rojas, Francisco M. Ortuņo Guzman, 2013.
Epigenetic variation represents a mechanism of regulation for genes expressed in different cancer histotypes. We considered breast cancer, and investigated differential expression following treatment with the 5-Aza-2'-deoxycytidine or DAC, a demethylating agent. Several oncogenic signalling pathways altered upon DAC treatment were detected with significant enrichment, and a regulatory map integrating Transcription Factors and microRNAs was derived. The ultimate goal is deciphering the potential molecular mechanisms induced by DAC therapy in MCF7 cells
Subject Systemd Biology
Bioinformatics & Computational biology

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