PUMA
Istituto di Fisiologia Clinica     
Ferrannini E., Gastaldelli A., Iozzo P. Pathophysiology of prediabetes. In: Medical Clinics of North America, vol. 95 (2) pp. 327 - 339, vii-viii. Elsevier Inc, 2011.
 
 
Abstract
(English)
Prediabetes encompasses conventional diagnostic categories of impaired fasting glucose and impaired glucose tolerance but is a band of glucose concentrations and a temporal phase over a continuum extending from conventional normal glucose tolerance to overt type 2 diabetes. Insulin resistance and defective glucose sensing at the beta-cell are the central pathophysiologic determinants that together cause hyperglycemia. Regardless of the cellular origin of insulin resistance, excessive tissue fat utilization is a consistent metabolic mechanism. Although genetic influences affect beta-cell function, becoming overweight is the main acquired challenge to insulin action. The phenotype of prediabetes includes dyslipidemia and higher arterial blood pressure.
URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21281836
Subject Blood Glucose/metabolism
Glucagon/metabolism
Insulin Resistance


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