Istituto di Fisiologia Clinica     
Corno A., Redaelli R., Caimi T., Mostarda G., Caruso R., Morra E. Sample carryover in PT-INR determination Is it an issue in Oral Anticoagulant Therapy control?. In: Thrombosis Research, vol. 127 pp. 279 - 281. Elsevier, 2011.
The quality of Oral Anticoagulant Therapy (OAT) management relies both on the adequacy (safety and effectiveness) of treatment and on the accuracy (precision and trueness) of PT-INR (Prothombin Time - International Normalized Ratio) determination. Since its introduction by Quick in 1935 [1], many efforts have been made to standardise the PT-INR method and to control the several preanalytical, analytical and post-analytical variables that may affect the assay results [2,3]. The introduction of automated techniques has greatly improved the throughput as well as the analytical performance of the assay. However, in some analysers, the robotic pipetting by means of a single sample probe, which comes into contact successively with different specimens, may lead to sample-to-sample carryover, which occurs when a portion of one specimen is transferred into the following one [4,5]. Sample carryover may impair the accuracy of the assay. Following the serendipitous observation of a sample carryover case while performing PT-INR determination, we decided to evaluate the impact of this phenomenon on plasmas from patients undergoing OAT control.
Subject oral anticoagulant therapy

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