Istituto di Fisiologia Clinica     
Bogazzi F., Rossi G., Lombardi M., Tomisti L., Sardella C., Manetti L., Curzio O., Marcocci C., Grasso L., Gasperi M., Martino E. Vitamin D status may contribute to serum igf1 concentrations in healthy subjects. In: Journal of Endocrinological Investigation, vol. 34 pp. e200- - 203. Editrice Kurtis, 2011.
Objective The aim of the study was to evaluate whether vitamin D [25-(OH) D3] status affects serum IGF1 concentrations in healthy subjects. Design and Patients Two hundred and forty one consecutive healthy subjects were included in the present study. Measurements Serum IGF1 and 25-(OH) D3 concentrations. Results As expected, serum IGF1 concentrations progressively decreased with age (r=-0.55, p<0.0001); on the contrary, gender was not related to serum IGF1 levels. A positive relationship was identified between serum 25-(OH) D3 and IGF1 concentrations (r=0.33, p<0.0001); the 25-(OH) D3 -dependent changes of serum IGF-1 concentrations were observed also when subjects were divided on the basis of vitamin D deficiency; in fact, those with severe 25-(OH) D3 deficiency (<20 ng/ml ) had lower (18583 microg/l) IGF1 values than those with mild-to absent 25-(OH) D3 deficit (22583 microg/l, p=0.0004). Conclusions 25-(OH) D3 status may contribute to determine serum IGF1 levels in healthy population.
DOI: 10.3275/7228
Subject IGF-I
Vitamin D

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