PUMA
Istituto di Fisiologia Clinica     
Liistro T., Guiducci L., Burchielli S., Panetta D., Belcari N., Pardini S., Del Guerra A., Salvadori P. A., Iozzo P. Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[18F]FDG study in Zucker and ZDF rats. In: Journal of Cerebral Blood Flow and Metabolism, vol. 30 pp. 895 - 899. Nature Publishing Group, 2010.
 
 
Abstract
(English)
Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with 18F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading.
DOI: 10.1038/jcbfm.2010.27
Subject Animals
Blood Glucose
Brain
Diabetes Mellitus, Type 2
Fasting
Fluorodeoxyglucose F18
Male
Obesity
Positron-Emission Tomography
Rats


Icona documento 1) Download Document PDF


Icona documento Open access Icona documento Restricted Icona documento Private

 


Per ulteriori informazioni, contattare: Librarian http://puma.isti.cnr.it

Valid HTML 4.0 Transitional