PUMA
Istituto di Fisiologia Clinica     
Gimelli A., Marzullo P., L' Abbate A., Rovai D. 'False-positive' myocardial perfusion imaging: correlation with cardiovascular risk factors and effect on event-free survival. In: Journal of Cardiovascular Medicine, vol. 9 pp. 707 - 713. Italian Federation of Cardiology, 2008.
 
 
Abstract
(English)
Background In the absence of significant coronary stenoses, stress-induced myocardial perfusion abnormalities at gated single photon emission computed tomography (g-SPECT) are usually considered to be a 'false-positive' result. Our goal was to investigate how falsepositive g-SPECT perfusion abnormalities relate to cardiovascular risk factors and whether they provide any prognostic information. Methods From 1999 to 2005, a group of 130 anginal patients with myocardial perfusion abnormalities at stress g-SPECT, with normal coronary angiography or less than 50% lumen reduction and with a left ventricular ejection fraction more than 0.45, was selected. The extent of myocardial perfusion abnormalities after stress was quantified using the summed difference score (SDS). cardiac events. An SDS more than 7 (P<0.0001) and diabetes mellitus (P<0.0001) were the only independent predictors of event-free survival using Cox proportional hazard regression analysis. Conclusion In patients with anginal-like chest pain and without significant coronary stenoses, stress-induced myocardial perfusion abnormalities at g-SPECT correlate with cardiovascular risk factors and are independent predictors of the few, minor adverse cardiac events during the follow-up.
URL: http://Italian federation of Cardiology
Subject angina
cardiovascular risk factors
myocardial perfusion
prognosis
single photon emission computed tomography


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