Istituto di Fisiologia Clinica     
Chiono V., Ciardelli G., Vozzi G., Sotgiu M. G., Vinci B., Domenici C., Giusti P. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(ε-caprolactone) blends for tissue engineering applications in the form of hollow fibres. In: Journal of Biomedical Materials Research Part A, vol. 85 A (4) pp. 938 - 953. Wiley Periodicals, Inc, 2008.
In this work, hollow fibers to be used as guides for tissue engineering applications were produced by dry-jet-wet spinning of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(ε-caprolactone) (PHBHV/PCL) solutions in chloroform with various weight ratios between the components (PHBHV/PCL 100/0; 80/20; 60/40; 50/50; 40/60; 20/80; 0/100 w/w). Fibers obtained from PHBHV/PCL blends had a low degree of surface and bulk porosity, depending on composition. Physico-chemical characterisation involving scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) showed that PHBHV/PCL blends are compatible. Interactions between blend components were studied by Fourier transform infrared total reflectance spectroscopy (FTIR-ATR), DSC analysis and polarised optical microscopy analysis. Homogeneity of blend composition was assessed by IR-Chemical Imaging analysis. PHBHV/PCL samples were found to be weakly hydrophilic and their biocompatibility was proved by in vitro tests using mouse fibroblasts. Mechanical properties of PHBHV/PCL blends were investigated by stress-strain tests, showing an increasing ductility of blend samples with increasing the PCL amount. Hollow fibres supported fibroblasts attachment and proliferation depending on composition and porosity degree.
Subject Polymer blends
Hollow fibers
Tissue engineering
Cell adhesion

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