Istituto di Fisiologia Clinica     
Pistelli F., Bottai M., Carrozzi L., Di Pede F., Baldacci S., Maio S., Brusasco V., Pellegrino R., Viegi G. Changes in obesity status and lung function decline in a general population sample. In: Respiratory Medicine, vol. 102 pp. 674 - 680. Elsevier, 2008.
Summary Aim of this paper was to evaluate the effects of changes in obesity status on lung function decline over an 8-year follow-up. Adults over 24 years (n 1212) from the general population, who participated in both Po River Delta first (PD1, 1980-1982) and second (PD2, 1988-1991)epidemiological surveys,were stratified as ''never obese'' (BMIo30 Kg/m2 at both PD1 and PD2), ''becoming obese''(BMIo30 Kg/m2 at PD1 and X30 Kg/m2 at PD2), ''always obese'' (BMIX30 Kg/m2 at both PD1 and PD2), and ''becoming non-obese'' (BMIX30 Kg/m2 at PD1 and o30 Kg/m2 at PD2). Linear regression models for changes in FEV1, FVC, and VC (computed as absolute differences between the values at PD2 and those at PD1) with longitudinal categories of obesity, gender, age, and baseline smoking habits as covariates were applied. The ''becoming obese'' and ''always obese'' categories had a significantly greater decline of lung function than ''never obese'' group; in the ''always obese'' group, this was true for vital capacities but not FEV1. Conversely, in the ''becoming non-obese'' group lung function was at PD2 improved with respect to PD1. Compared with ''Never obese'' the mean increase in lung function was of 93, 180, and 48 mL for FEV1, FVC, and VC,respectively. In this general population sample, remaining or becoming obese increases the decline in lung function over 8 years, while becoming non-obese decreases it.
Subject Body mass index
Longitudinal studies

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