Istituto di Fisiologia Clinica     
Del Ry S., Maltinti M., Cabiati M., Emdin M., Giannessi D., Morales M. A. C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure. In: Peptides, vol. 29 pp. 79 - 82. Elsevier, 2008.
C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF)patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well as less load independent parameters as dP/dt. LV ejection fraction (EF), left ventricular end-diastolic dimension (LVEDD) and LV dP/dt were evaluated together with plasma CNP levels in 38 patients with CHF and in 63 controls. CNP levels resulted significantly higher in CHF patients than in controls (7.19 0.59 pg/ml vs. 2.52 0.12 pg/ml, p < 0.0001). A significant correlation between dP/dt and CNP levels (r = 0.61, p < 0.0001) was observed. A good correlation with EF (r = 0.55, p < 0.001) and a less significant relation with LVEDD (r = 0.316, p < 0.05) were also reported. When patients were divided according to dP/dt values a very significant difference in CNP levels was observed: Group I (<600, n = 25) vs. Group II (>600, n = 13): 8.46 0.69 and 4.75 0.75 pg/ml, respectively, p < 0.001. This is the first study that reports a correlation between CNP and dP/ dt in CHF patients, thus suggesting a possible role on cardiac contractility.
URL: http://journal homepage: www.elsevier.com/locate/peptides
Subject Chronic heart failure (CHF)
C-type natriuretic peptide (CNP)
Radioimmunoassay (RIA)
Cardiac echo-Doppler

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