Istituto di Fisiologia Clinica     
Scarcello E., Triggiani G., Arispici M., Bertini L., Bosi F., Bernini F., Salvadori C., Trivella M. G. Experimental Study of a New Vascular Anastomotic Technique in a Swine Model: Short and Mid-Term Results. In: Annals of Vascular Surgery, vol. 21 (3) pp. 346 - 351. Elsevier, 2007.
This study reports thè development of a new open external vascular stent: thè lock stent device (LSD). It enables a novel end-to-end sleeve anastomotic technique, named locked anastomosis (LA). The LA technique consists of inserting a graft sleeve within an artery, secured in piace by an internai stent and an extemal LSD. The internai stent, graft, vessel wall, and LSD are fastened together with single sutures. The LSD placement does not require a complete transection of thè vessel wall as it can be enlarged and then relaxed to clasp thè vessel neck. The tensile strength of thè LA technique was accurately measured ex vivo and its stability successfully tested in vivo by acute pressure peak tests and mid-term survival studies. Ex vivo, thè ratio between thè tensile strength of thè LA technique with two, three, and six stitches and that of hand-sewn anastomoses was 0.41 ± 0.02,0.59 ± 0.17, and 1.03 ± 0.04. In vivo, LA anastomoses folerated marked increases in blood pressure (peak systolic pressure 195-230 mm Hg) for periods of 15-25 min without leakage. Pive pigs survived 10 weeks with abdominal aorto-aortic bypass performed according to thè LA technique with three stitches. Aortograms showed no narrowing orthromboses, and histological findings confimi uniform flattening of thè aortic wall at thè anastomosis, with proliferating neointima and uniformty hypotrophic media. Minimal changes were observed in thè adventitia.
URL: http://www.elsevier.com
DOI: 10.1016/j.avsg.2006.08.009
Subject LSD

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