Istituto di Fisiologia Clinica     
Longo V., Chirulli V., Gervasi P. G., Nencioni S., Pellegrini M. Lisosan G, a powder of grain, does not interfer with the drug metabolizing enzymes and has a protective role on carbon tetrachloride-induced hepatotoxicity. In: Biotechnology Letters, vol. 29 pp. 1155 - 1159. Springer Science+Business Media B.V, 2007.
Lisosan G is a powder of grain registered as an alimentary integrator. The treatment of rats for 4 days with 0.5 g Lisosan G/kg had no effect on various drug metabolizing enzymes. Experiments in vitro showed that Lisosan G had radical scavenger activity. A confirmation of the antioxidative prop-erty of Lisosan G was also confirmed when it was administered in vivo to carbon tetrachloride (CCl4 )-intoxicated rats. The toxicity caused by CCl4 -treatment of rats was restored to the control levels when the rats were given Lisosan G for 4 days before CCl4 . Lisosan G thus does not interfer with drug metabolizing system but has antioxidant properties and protects against CCl4 -induced hepatotoxicity.
DOI: DOI 10.1007/s10529-007-9378-6
Subject Antioxidant activity
Drug-metabolizing enzymes
Lisosan G

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