Istituto di Fisiologia Clinica     
Moreo A., De Chiara B., Possa M., Sara R., Bossi I., Silva Orrego P., Nicolosi E., Mauri F., Parodi O. Functional derangement and cardiac innervation in the apical ballooning syndrome: a 123I-meta-iodobenzylguanidine scintigraphic and dobutamine stress echocardiographic study. In: Journal of Cardiovascular Medicine, vol. 8 (3) pp. 205 - 209. Italian Federation of Cardiology, 2007.
Several cases of transient left ventricular apical ballooning syndrome have already been described, but the pathophysiological mechanisms of this syndrome still remain unclear. We report the case of a patient evaluated in the acute phase of apical ballooning by coronary angiography and echocardiography who was submitted to 123I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy and dobutamine stress echocardiography one month after the discharge. MIBG scintigraphy demonstrated a decreased tracer uptake in the apical and periapical anterior regions, whilst myocardial perfusion at rest was normal. Dobutamine induced an increased left ventricular outflow tract gradient and hypokinesis in the apical and periapical segments, mimicking the findings that occurred in the acute phase, and in agreement with the location of MIBG abnormalities. After a two-month treatment with carvedilol, MIBG uptake increased in the apical and periapical anterior regions.
Subject apical ballooning syndrome
dobutamine stress echocardiography
MIBG scintigraphy

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