PUMA
Istituto di Fisiologia Clinica     
Simoni M., Baldacci S., Puntoni R., Pistelli F., Farchi S., Lo Presti E., Pistelli R., Gorbo G., Agabiti N., Basso S., Matteelli G., Di Pede F., Carrozzi L., Forestiere F., Viegi G. Plasma salivary and urinary in non smoke Italian women and unesposed to environmental tobacco smoking (SEASD study). In: Clinical Chemistry Laboratory Medicine, vol. 44 (5) pp. 632 - 638w. Walter de Gruyter, 2006.
 
 
Abstract
(English)
Abstract Background: The aim of this study was to compare cotinine determinations in three biological fluids for assessing environmental tobacco smoke (ETS) exposure in female non-smokers (ns1605) in Italy. Methods: Information about ETS exposure at home, in the workplace, and in other places within the previous week was collected via questionnaire. Plasma, salivary and urinary cotinine levels were measured. Cotinine levels ofG0.1 ng/mL for plasma,G0.2 ng/mL for saliva, and G0.5 ng/mL for urine were used to determine biochemical exposure. Results: Median cotinine levels were significantly higher in exposed than in unexposed women (0.21 vs. 0.05 ng/mL in plasma, 0.80 vs. 0.41 ng/mL in saliva, and 9.74 vs. 5.30 ng/mL in urine). Self-reported ETS exposure was significantly related to biochemical exposure wodds ratio 2.99, (95% CI 2.40-3.72) for plasma; 1.90 (1.51-2.39) for saliva; and 2.67 (2.14-3.34) for urinex. Cotinine significantly increased with increasing exposure level, regardless of the exposure source. Among self-reported exposed subjects, higher percentages of cotinine level above the cut-off, i.e., 1) SEASD Group: G. Viegi (Pisa), F. Forastiere (Rome), S. Mallone (Rome), E. Lo Presti (Rome), S. Baldacci (Pisa), F. Pistelli (Pisa), M. Simoni (Pisa), A. Scalera (Pisa), M. Pedreschi (Pisa), R. Pistelli (Rome), G. Corbo (Rome), E. Rapiti (Rome), N. Agabiti (Rome), S. Farchi (Rome), S. Basso (Rome), L. Chiaffi (Pisa), G. Matteelli (Pisa), F. Di Pede (Pisa), L. Carrozzi (Pisa), R. Puntoni (Pisa), A. Bigazzi (Pisa), T. Sampietro (Pisa), R. Licitra (Pisa), F. Bigazzi (Pisa), A. Patricelli (Pisa), A. Rossellini (Pisa), A. Angino (Pisa), B. Attisani (Pisa), F. Martini (Pisa), B. Piegaia (Pisa), G. Lazzeri (Pisa), P. Silvi (Pisa), L. Zen (Ferrara), E. Baraldi (Ferrara), M.T. Prosdocimi (Ferrara), A. Quercia (Viterbo). *Corresponding author: Dr. Giovanni Viegi, Istituto di Fisiologia Clinica CNR, Via Trieste, 41, 56126 Pisa, Italy Phone: q39-050-502031/913632, Fax: q39-050-503596, E-mail: viegig@ifc.cnr.it indicating exposure, were found in saliva (76%) and urine (75%) than in plasma (52%). Conclusions: In general, women correctly reported their ETS exposure status. Both non-invasive salivary and urinary cotinine determinations seem preferable in epidemiological studies, in view of their higher sensitivity, when compared to plasma cotinine.
URL: http://www.de Gruyter.com
Subject Somking
Exposure
Tobacco
Environment
smokering


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