Istituto di Fisiologia Clinica     
Clerico A., Zucchelli G. C., Pilo A., Emdin M. Clinical relevance of biological variation of B-Type natriuretic peptide. In: Clinical Chemistry, vol. 51 (05) pp. 925 - 926. American Association for Clinical Chemistry, 2005.
The cardiac natriuretic hormones (CNHs), atrial (ANP) and B-type natriuretic peptide (BNP), are peptides produced and secreted by the atrial and ventricular cardiomyocytes, respectively. ANP and BNP share potent diuretic, natriuretic, and vascular smooth-muscle-relaxing effects and interact with the hormonal and nervous systems (1)(2)(3). Stimulation by hemodynamic overload, as well as by several neuroendocrine (including {alpha}-adrenergic agonists, angiotensin II, endothelins, and vasopressin) and immunologic agents and by growth factors, modulates the production of CNHs by the human heart (1)(2). CNHs and their respective counter-regulatory neurohormonal systems (including the adrenergic, endothelin, and renin-angiotensin-aldosterone systems) form a physiologic negative feedback mechanism that regulates cardiac output by controlling blood pressure and heart rate as well as by fluid and electrolyte homeostasis (1)(2).
URL: http://www.clinchem.org/cgi/reprint/51/5/925?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=clerico&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=51&resourcetype=HWCIT
Subject Clinical Relevance
Biological Variation

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