Istituto di Fisiologia Clinica     
Andreassi M. G., Cioppa A., Botto N., Joksic G., Manfredi S., Federici C., Ostojic M., Rubino P., Picano E. Somatic DNA damage in interventional cardiologists: a case-control study. In: The Faseb Journal, vol. 19 (08) pp. 998 - 999. The Federation of American Societies for Experimental Biology, 2005.
SPECIFIC AIMS Invasive cardiologists working in a busy catheterization laboratories represent, perhaps, the extreme far end (with the highest exposure) of the spectrum of medical radiation workers. The average exposure is 2-3 times higher than that of radiologists and has increased steadily in the past 20 years. With few exceptions, in hospitals with invasive cardiology facilities, badges that exceed the level 1 ALARA (as low as reasonably achievable) limits (<6 mSv/year) are worn by invasive cardiologists. This implies that cardiologists are exposed to significant levels of radiation, which could pose a health hazard if they do not abide by standard safety precautions. Damage to DNA is considered to be the main initiating event by which radiation damage to cells results in the development of cancer and hereditary disease. The yield of chromosomal aberrations is a strong predictor of cancer risk in humans. Chromosomal abnormalities can reliably be assessed by evaluating the frequency of micronuclei (MNs) in dividing cells because MNs mainly originate from chromosome breaks or whole chromosomes that fail to engage with the mitotic spindle when the cell divides. The aim of the present study was to assess the effects of chronic low dose X-ray radiation exposure on MN frequency of invasive cardiologists working in three high volume cardiac catheterization laboratories. PRINCIPAL FINDINGS 1. Interventional cardiologists working in a large volume catheterization laboratory have higher levels of somatic DNA damage when compared with clinical cardiologists working outside the catheterization lab We obtained peripheral blood from 62 physicians (age=40.61.5 years): 31 interventional cardiologists (Group I, exposed) and 31 clinical cardiologists (Group II, nonexposed). Exposed and control groups were comparable for baseline characteristics, including age, gender, smoking status, and years of hospital work. No subjects had a personal medical history of disease, cancer, or recent infectious state. In the exposed physicians, the mean cumulative equivalent doses over the last year was 4.06 0.4 mSv.
URL: http://www.fasebj.org/cgi/reprint/19/8/998
Subject Somatic

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