PUMA
Istituto di Fisiologia Clinica     
Pepe A., Lombardi M., Takacs I., Positano V., Panzarella G., Picano E. Nitrate-induced coronary vasodilation by stress-magnetic resonance imaging: A novel noninvasive test of coronary vasomotion. In: Journal of Magnetic Resonance Imaging, vol. 20 pp. 390 - 394. Wiley & Sons, 2004.
 
 
Abstract
(English)
Purpose To evaluate the feasibility of assessing coronary vasodilation following exogenous nitrates, using magnetic resonance angiography (MRA). The assessment of coronary response to exogenous nitrovasodilators may have a diagnostic and prognostic impact in patients with coronary artery disease. To date, stress imaging of coronary artery vasomotion has been confined to the catheterization laboratory. MRA is emerging as a noninvasive tool for coronary artery imaging. Materials and Methods Coronary MRA was performed in 20 healthy volunteers (12 males, age = 33 8). We used spiral spoiled gradient echo (SSGE) sequences for imaging of coronary artery lumen. After the baseline short-axis view of the coronary artery was obtained, sublingual nitroglycerin (NTG) (0.3 mg) was administered. In all subjects, short-axis views of the coronary artery were acquired repetitively (8-10 times) from 1 up to 10 minutes after NTG administration. Measurements were obtained by two independent investigators. Results Interpretable short-axis view of left anterior descending artery (LAD) was obtained in 15 subjects (75%); in the remaining five subjects the right coronary artery (RCA) was examined. The interobserver variability was 15%, and the intraobserver variability 4%. The NTG-induced maximal vasodilation was 43 22%. The vasodilator response over time after NTG was maximal on average at 279 112 seconds, but with substantial heterogeneity. Conclusion Entity and time course of nitrate-induced coronary vasodilation in the left anterior descending and/or RCA can be assessed using MRA with high feasibility and reproducibility. Coronary MRA has potential for dynamic imaging of coronary vasomotion.
URL: http://www3.interscience.wiley.com/cgi-bin/fulltext/109595596/PDFSTART
Subject Coronary
magnetic resonance angiography
nitrate


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