Istituto di Fisiologia Clinica     
Fabian E., Varga A., Picano E., Vajo Z., Ronaszeki A., Csanady M. Effect of simvastatin on endothelial function in cardiac syndrome X patients. In: The American Journal of Cardiology, vol. 94 (05) pp. 652 - 655. Elsevier Inc, 2004.
Patients with cardiac syndrome X with mild hypercholesterolemia were randomized to placebo (n = 20) or simvastatin 20 mg/day (n = 20). In the simvastatin group, there was a significant (26%; p <0.0001) decrease in total cholesterol, a 38% (p <0.0001) decrease in low-density lipoprotein cholesterol levels, and 7% a (p <0.0001) increase in high-density lipoprotein cholesterol levels, without significant changes in triglyceride levels. Brachial artery flow-mediated dilation increased significantly (52% relative increase, p <0.0001), and the time to >1-mm ST-segment depression during stress testing was longer by the end of the study (p <0.0001).
URL: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T10-4D75HW6-T-7&_cdi=4876&_user=10&_orig=search&_coverDate=09%2F01%2F2004&_qd=1&_sk=999059994&view=c&_alid=473564304&_rdoc=1&wchp=dGLbVzz-zSkzk&md5=873f7a10f6a414ffc966e951c3e73b48&ie=/sdarticle.pd
Subject artery
endothelial function

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