Istituto di Fisiologia Clinica     
Picano E. Diabetic cardiomyopathy the importance of being earlies. In: Journal of American College Cardiology, vol. 42 (03) pp. 454 - 457. American College of Cardiology Foundation, 2003.
Over the years, the existence of a diabetic cardiomyopathy distinct from ischemic injury has been confirmed (1), but the challenge of recognizing diabetic cardiomyopathy at an early stage, in a noninvasive way, still remains. In this issue of the Journal, Fang et al. (2) evaluated 41 diabetic patients and 41 matched control subjects with standard echocardio- graphic rest and dobutamine tissue Doppler-derived indices of systolic and diastolic left ventricular (LV) function. In that study, the diabetic patients, compared with control subjects at rest, showed an impairment of peak myocardial systolic velocity and early diastolic velocity. However, in the diabetic group and in the control group, the dobutamine-induced increases in both peak systolic and early diastolic velocity were similar. The study comes from a well-known laboratory and addresses an important, yet still elusive, clinical target: the pre-clinical objective identification of diabetic cardiomyopathy. The results obtained are interesting, as the study outlines a novel approach for the identification of early incipient diabetic cardiomyopathy, supporting the physician with suitable end points to test new preventive and therapeutic approaches in these patients.
URL: http://content.onlinejacc.org/cgi/reprint/42/3/454
Subject Diabetic

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