Istituto di Fisiologia Clinica     
Emdin M., Passino C., Donato L., Paolicchi A., Pompella A. Serum gamma-glutamyltransferase as a risk factor of ischemic stroke might be independent of alcohol consumption. In: Stroke, vol. 33 pp. 1163 - 1164. american heart association, 2002.
In a recent issue of Stroke, Jousilahti et al reported on the association of stroke with serum levels of gamma-glutamyltransferase (GGT) and alcohol consumption in a cohort of more than 14 000 subjects.1 In particular, the authors observed that the incidence of ischemic stroke had a good correlation with serum GGT-which they interpreted as a surrogate marker of alcohol consumption-in both genders (relative risk in men 1.29, 95% CI 1.04 to 1.60; in women 1.42, 95% CI 1.10 to 1.84). On the other hand, no correlation of ischemic stroke was observed with the self-reported individual alcohol intakes, although "a significant linear increasing trend in the mean levels of self-reported alcohol drinking by quartiles of the serum GGT" was found. The obvious conclusion is that GGT is an independent risk factor for ischemic stroke, irrespective of alcohol drinking, whereas the authors concluded that answers given by patients to questionnaires concerning their lifestyles are unreliable and that serum GGT is a more faithful indicator of alcohol consumption, ie, the actual determinant of stroke occurrence.
URL: http://stroke.ahajournals.org/cgi/reprint/33/4/1163
Subject Stroke

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