Istituto di Fisiologia Clinica     
Toschi E., Camastra S., Mari A., Gastaldelli A., Baldi S., Masoni A., Ferrannini E. A model for assessing insulin secretion and its control under free-living conditions. In: Diabetes, vol. 50 (supplement 1) pp. s178 - s179. The American Diabetes Association, 2001.
A well-established approach for the estimation of insulin secretion in vivo is based on the measurement of plasma C-peptide. C-peptide is secreted by pancreatic beta-cells in equimolar amounts with insulin, but unlike insulin, C-peptide is not extracted by the liver and has a constant peripheral clearance. Thus, the systemic (venous) appearance of C-peptide equals the pancreatic release of insulin. The C-peptide systemic appearance can be calculated by deconvolution from the plasma C-peptide concentrations and a kinetic model of C-peptide distribution (1). This method has been used to evaluate 24-h profiles of insulin secretion (2) and the beta-cell dose-response curve (3). We developed a model for assessing the 24-h profile of insulin secretion and its control by glucose, simultaneously. To date, the model has been tested in lean and obese nondiabetic subjects.
URL: http://diabetes.diabetesjournals.org/cgi/reprint/50/suppl_1/S178
Subject insulin

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