Istituto di Fisiologia Clinica     
Rodriguez O., Picano E., Fedele S., Morelos M., Marzilli M., Ungi I. Non-invasive prediction of angiographic progression of coronary artery disease by dipyridamole-stress echocardiography. In: Coronary Artery Disease, vol. 12 (03) pp. 197 - 204. Lippincott Williams & Wilkins, Inc, 2001.
Background: Coronary angiography is the currently accepted standard means for assessing progression of coronary artery disease. A dipyridamole-echocardiography test (DET) might provide an alternative non-invasive functional imaging method for this purpose. Objective: To assess whether variations in results of serial DET match variations in angiographic assessments of coronary artery disease. Methods: From the Pisa Institute of Clinical Physiology stress-echocardiography data bank (1983-1998), we selected 60 patients satisfying the inclusion criteria of coronary angiography and DET having each been performed and interpreted twice independently and within 1 week. The second angiographic and stress-echocardiographic assessment was performed 45 +/- 31 months after the initial one. Angiographic progressors were defined a priori as patients with any progression of stenosis to occlusion and those with any stenosis > 30% with > 20% progression of stenosis measured by visual and quantitative coronary angiography. Stress-echocardiography progressors were defined as those patients who had previously had a negative test of a test having a positive result and those patients who had positive results of tests both in initial testing and in a second session of testing with the latter having a peak wall-motion-score index > 0.12 (on a scale of 1, normal to 4, dyskinetic in a 16-segment model) larger than the former. Results: Of the 60 patients, 44 were angiographic 'progressors' and 16 were 'non progressors'. Stress-echocardiographic responses were concordant with angiographic identification for 39 of 44 progressors and 15 of 16 non-progressors, with an overall concordance of 90%. Conclusions: Measurement of dipyridamole-stress-echocardiographic response allows one to separate angiographic progressors and non-progressors efficiently, simply by taking into account the presence, extent and severity of stress-induced abnormalities of wall motion.
URL: http://www.coronary-artery.com/pt/re/cad/pdfhandler.00019501-200105000-00006.pdf;jsessionid=F0QcDsMMBy22JPb1mxTJRvqsy0bZhtl9mZk55jt7DdwkB5jnLNhR!1299987372!-949856145!8091!-1?&nav=search&searchid=5&index=1&results=1&count=10
Subject Coronary artery disease

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