PUMA
Istituto di Fisiologia Clinica     
Piffanelli A., Morganti A., Mantero F., Cianetti A., Zucchelli G. C., Giovannini G., Pellizola D. Supraregional interlaboratory quality-control survey for an immunoradiometric renin assay. In: Clinical Chemistry, vol. 47 (12) pp. 2148 - 2150. American Association for Clinical Chemistry, 2001.
 
 
Abstract
(English)
For the last 20 years, the most widely used method for assessment of the renin-angiotensin system has been the plasma renin activity assay (1 ). Although the assay gives useful information on the enzymatic function of the renin molecule, the intrinsic characteristics of this method limit its analytical accuracy (2 ). Immunoradiometric assays for renin, developed in 1985, overcame this limitation of the enzymatic assay because the well-defined monoclonal antibodies provided the means for direct quantification of specific active forms of the enzyme molecule (3, 4). Nevertheless, a critical debate has developed over the use of these assays (5-10).
URL: http://www.clinchem.org/cgi/reprint/47/12/2148?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=47&firstpage=2148&resourcetype=HWCIT
Subject renal functions
Patients


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