Istituto di Fisiologia Clinica     
Laghi-Pasini F., Guideri F., Picano E., Parenti G., Petersen C., Varga A., Di Perri T. Increase in plasma adenosine during brain ischemia in man: a study during transient ischemic attacks, and stroke. In: Brain Reseach Bulletin, vol. 51 (04) pp. 327 - 330. else, 2000.
evaluated in the clinical models of transient ischemic attack (TIA) and stroke, respectively-acutely raise plasma adenosine levels. We studied 20 patients: 10 with TIA and 10 with stroke. In all, blood was serially sampled for assessment of plasma adenosine by an high-performance liquid chromatography method. Sampling occurred on peripheral blood during TIA and stroke upon admission, and serially thereafter every day up to 7 days and every other day up to 20 days. We found that in TIA and stroke patients, peripheral adenosine levels were increased to a similar extent upon admission (TIA = 264 53 vs. stroke = 257 60 nM, p = ns), peaked on the day 2 for TIA (300 60) and on day 3 for stroke (289 43) patients, and steadily decreased towards the normal range, reached by all TIA patients by day 5 and by stroke patients by day 15. Stroke and TIA are associated with a rapid increase in circulating plasma adenosine concentration in man, detectable in peripheral vein. The adenosine surge likely mirrors an increased production from the ischemic brain, and it lasts days (for TIA) and weeks (for stroke) after the acute event.
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Subject Adenosine

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