Istituto di Fisiologia Clinica     
Lorente C., Cordier S., Goujard J., Ayme S., Bianchi F., Calzolari E., De Walle H., Knill-Jones R. Tobacco and alcohol use during pregnancy and risk of oral clefts. In: American Journal of Public Health, vol. 90 (03) pp. 415 - 419. American Public Health Association, 2000.
OBJECTIVES: This study examined the relationship between maternal tobacco and alcohol consumption during the first trimester of pregnancy and oral clefts. METHODS: Data were derived from a European multicenter case-control study including 161 infants with oral clefts and 1134 control infants. RESULTS: Multivariate analyses showed an increased risk of cleft lip with or without cleft palate associated with smoking (odds ratio [OR] = 1.79, 95% confidence interval [CI] = 1.07, 3.04) and an increased risk of cleft palate associated with alcohol consumption (OR = 2.28, 95% CI = 1.02, 5.09). The former risk increased with the number of cigarettes smoked. CONCLUSIONS: This study provides further evidence of the possible role of prevalent environmental exposures such as tobacco and alcohol in the etiology of oral clefts.
URL: http://www.ajph.org/cgi/reprint/90/3/415
Subject Tobacco

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