PUMA
Istituto di Biofisica     
Eventi A., Lubrano V., Scarpato R., Turchi G. Protective effects of plicatin B on micronucleus induction in cultured human lymphocytes by different mutagens. In: Food and Chemical Toxicology, vol. 47 (1) pp. 124 - 128. Elsevier, 2009.
 
 
Abstract
(English)
Among flavonoids, chalcones have been identified as interesting compounds having antioxidant, antimutagenic and antitumour properties. In this study we have evaluated the clastogenicity of plicatin B on human lymphocytes (whole blood and isolated lymphocytes) and its anticlastogenic activity, in the same cellular systems, using mitomycin C (MMC), radio-mimetic bleomycin (BL) and hydrogen peroxide (H2O2) as reference clastogens. Plicatin B per se resulted cytotoxic at high dose but non-clastogenic. The clastogenic effects induced by MMC and BL were significantly reduced (-33%) whereas with H2O2 the protective effect of plicatin B was observed (-62%) only at the greater H2O2 dose. The anticlastogen effects of plicatin B were effective when the chalcone was introduced in the culture,1 h before the reference clastogens.
URL: http://www.sciencedirect.com/science?_ob=PublicationURL&_tockey=%23TOC%235036%232009%23999529998%23820098%23FLA%23&_cdi=5036&_pubType=J&_auth=y&_acct=C000061181&_version=1&_urlVersion=0&_userid=3967543&md5=e06c7fdf60585c632e8c85d061801b72
DOI: 10.1016/j.fct.2008.10.017
Subject Chalcone plicatin B
Cytotoxicity
Micronucleus


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