Istituto di Biofisica     
Di Garbo A., Barbi M., Chillemi S. Signal processing properties of fast spiking interneurons. In: Biosystems, vol. 86 (1-3) pp. 27 - 37. Elsevier Science, 2006.
Fast spiking interneurons receive excitatory synaptic inputs from pyramidal cells and a relevant problem is to understand how these cells readout this information. Here this topic is investigated theoretically by using a biophysical modeling of a pair of coupled fast spiking interneuron models. The model predicts, in agreement with the experimental findings, that these cells are capable of transmitting pre-synaptic signals with high temporal precision and transferring high frequency inputs while preserving their relative timing. Moreover, it is shown that a pair of fast spiking interneurons, coupled through both inhibitory and electrical synapses, behaves as a coincidence detector. Lastly, to understand the mechanisms underlying these phenomena, a theoretical analysis is carried out by using a simpler modeling approach.
DOI: 10.1016/j.biosystems.2006.03.009
Subject Fast spiking interneuron
Gap junctions
Spike transmission
Coincidence detection

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